Induction of classical transplantation tolerance in the adult.

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Induction of classical transplantation tolerance in the adult

Transplantation tolerance across histoincompatibilities in multiple non-H-2 minors (B10.BR into CBA/Ca) and "minor" plus H-2D (B10.A into CBA/Ca) antigens has been achieved successfully by combined adult bone marrow transplantation and treatment with CD4 and CD8 mAbs. The tolerant state was confirmed by permanent acceptance of donor strain skin grafts, and in vitro unresponsiveness to donor cel...

متن کامل

Induction of Classical Transplantation Tolerance in the Adult by Shixin Qin, Steve Cobbold, Richard Benjamin, and Herman Waldmann

Clinical organ transplantation between genetically disparate individuals presently requires nonspecific immunosuppressive agents to prevent rejection . However, the use of such agents risks morbidity and mortality from a range of associated side effects and does not always guarantee success of the graft. Therefore, there is a need to establish methods of "donor-specific transplantation toleranc...

متن کامل

Stem Cell-based Tolerance Induction in Transplantation

The use of stem cell-based protocols in transplantation has rapidly achieved many long-sought goals, including the induction of donor-specific tolerance and as an effective immunomodulatory therapy against acute cellular rejection and graft-versus-host disease. Recent advances in the fields of transplant immunology and regenerative medicine have significantly improved outcomes after solid organ...

متن کامل

Chimerism and tolerance induction in kidney transplantation.

Chimerism is a state in which bone marrow hematopoietic stem cells from two genetically different animals coexist. To date, the approach has been used successfully to induce the state of immunologic tolerance in the animal models and is now being evaluated in clinical trials of both HLA-identical and HLA-mismatched living-donor kidney transplant recipients in some transplant centers with varyin...

متن کامل

Induction of immunologic tolerance for transplantation.

In the second half of the 20th century, the transplantation of replacement organs and tissues to cure disease has become a clinical reality. Success has been achieved as a direct result of progress in understanding the cellular and molecular biology of the immune system. This understanding has led to the development of immunosuppressive pharmaceuticals that are part of nearly every transplantat...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1989

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.169.3.779